Investigation of the efficacy and safety of a bi-hormonal contraceptive drug in a long-term experiment

The efficacy and safety of the SEX BARRIER, bi-hormonal contraceptive drug, for cats, which was used during more than two years (from June 2016 to November 2018), was investigated. Materials and methods. The doses of preparation and schemes of its applications (to interrupt and to prevent the heat) were used according the instruction. In the course of entire study we carried out a constant observation of the heat manifestations, periodically (once every two months) ― the complete clinical examination of animals, the ultrasound procedure of reproductive organs, the vaginal cytology, the clinical and biochemical analyses of the blood, and also the level of sex steroids was determined. Results. Stable suppression of all signs of estrous behavior in cats treated with the drug was observed, which correspond with the vaginal smears and basal levels of estradiol and progesterone in animals throughout the entire study period, which clearly confirms the high efficacy of the drug. The absence of pathological changes in the structure of the ovaries and uterus according to the results of clinical examinations, data of ultrasonography of the pelvic organs, the stability of the main blood parameters, while maintaining their compliance with the physiological norm during the entire study time, and fast (during 3 ... 4 weeks after stopping long-term use of the drug) recovery of the estrous cycle serves as convincing evidence of the safety of long-term use of the bi-hormonal drug for the correction of sexual function in cats.