Open AccessCOVID-19 AND CANCER COMORBIDITY: THERAPEUTIC OPPORTUNITIES AND CHALLENGES (RUSSIAN TRANSLATION)
Author(s) -
Anup Singh Pathania,
Philip Prathipati,
Bakrudeen Ali Ahmed Abdul,
Srinivas Chava,
Santharam S. Katta,
Subash C. Gupta,
Pandu R. Gangula,
Manoj K. Pandey,
Donald L. Durden,
Siddappa N. Byrareddy,
Kishore B. Challagundla
Publication year - 2021
Publication title -
juvenis scientia
Language(s) - English
Resource type - Journals
eISSN - 2414-3790
pISSN - 2414-3782
DOI - 10.32415/jscientia_2021_7_6_28-70
Subject(s) - pandemic , comorbidity , medicine , disease , cancer , covid-19 , coronavirus , outbreak , intensive care medicine , virology , infectious disease (medical specialty)
The coronavirus disease 2019 (COVID-19) is a viral disease caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that affects the respiratory system of infected individuals. COVID-19 spreads between humans through respiratory droplets produced when an infected person coughs or sneezes. The COVID-19 outbreak originated in Wuhan, China at the end of 2019. As of 29 Sept 2020, over 235 countries, areas or territories across the globe reported a total of 33,441,919 confirmed cases, and 1,003,497 confirmed deaths due to COVID-19. Individuals of all ages are at risk for infection, but in most cases disease severity is associated with age and pre-existing diseases that compromise immunity, like cancer. Numerous reports suggest that people with cancer can be at higher risk of severe illness and related deaths from COVID-19. Therefore, managing cancer care under this pandemic is challenging and requires a collaborative multidisciplinary approach for optimal care of cancer patients in hospital settings. In this comprehensive review, we discuss the impact of the COVID-19 pandemic on cancer patients, their care, and treatment. Further, this review covers the SARS-CoV-2 pandemic, genome characterization, COVID-19 pathophysiology, and associated signaling pathways in cancer, and the choice of anticancer agents as repurposed drugs for treating COVID-19. Original article: Pathania AS, Prathipati P, Abdul BAA, et al. COVID-19 and Cancer Comorbidity: Therapeutic Opportunities and Challenges. Theranostics. 2021;11(2):731-753. DOI: 10.7150/thno.51471. The article was translated into Russian and published under the terms of the Creative Commons Attribution 4.0 license.