ASSESSMENT OF THE STATE OF THE SKIN MICROBIOME OF PATIENTS WITH ALLERGODERMATOSES

. Recently, special attention has been paid to opportunistic microorganisms that inhabit biosubstrates - the skin and mucous membranes of the human body. Patients and Methods . To assess the microbiome of the skin in patients with allergic dermatoses, we carried out microbiological studies of the skin in 456 patients aged from 3 to 67 years. Microbiological studies included bacterioscopic and cultural examination of skin flakes from lesions in patients with allergic dermatoses. Results . Our clinical and microbiological studies of 456 patients with allergic dermatoses showed that Staphylococcus spp. was detected on the skin lesions of 429 patients (94.08%), including those with atopic dermatitis - 230 (53.61%), urticaria - 47 (10.96%), toxicoderma - 48 (11.19%) and erythema multiforme - 22 (5.13%). The most common species of microorganisms observed in patients with allergic dermatoses included S. aureus in 46.6% (200) and S. epidermidis in 29.1% (125) cases, followed by S. haemolyticus in 14.2% (61), S. saprophyticus in 5.6% (24), Enterobacter in 3.9% (17) and S. pyogenes in 0.5% (2) patients. In 34.8% of cases, we found microbial contamination with pathogenic forms of Staphylococcus spp. , which determined the development of a mixed-bacterial form of an invasive process in the skin lesions of patients with allergic dermatoses. Conclusion . The data obtained are of great importance with regard to the clinical course of allergic dermatoses and will contribute to the development of new methods of pathogenetic therapy.