Open AccessModeling of a Different Volume Spinal Cord Injury in Rats and Methods for Evaluation of Lost Functions Restoration
Author(s) -
С. Миронов,
С. В. Колесов,
Г. А. Степанов,
М. Л. Сажнев,
С. П. Губин,
Yu. V. Ionin,
В. Г. Мотин,
А. А. Пантелеев
Publication year - 2015
Publication title -
vestnik travmatologii i ortopedii imeni n.n. priorova
Language(s) - English
Resource type - Journals
eISSN - 2658-6738
pISSN - 0869-8678
DOI - 10.32414/0869-8678-2015-3-73-77
Subject(s) - spinal cord injury , spinal cord , cord , animal model , reproducibility , volume (thermodynamics) , medicine , physical medicine and rehabilitation , anatomy , anesthesia , surgery , mathematics , physics , statistics , quantum mechanics , psychiatry
The method for modelling of a different volume spinal cord injury to study potentialities for its regeneration is presented. The work was performed on 80 laboratory rats divided into 5 groups according to the volume of inflicted injury. Original instrument with restrictors for the infliction of the accurate and measured by volume spinal cord injuries was elaborated. The degree of function restoration was evaluated by the results of visual assessment of the movements in animals’ hind paws, records of induced potentials of the cerebral cortex region and by BBB scale. In every separate group the obtained indices were distributed uniformly that indicated justifiability and reproducibility of the elaborated model of incomplete spinal cord injury.