Open AccessEfficacy of Gen-Activated Osteoplastic Material Based on Octacalcium Phosphate and Plasmid DNA containing vegf Gene for Critical-sized Bone Defects Substitution
Author(s) -
И Я Бозо,
Р. В. Деев,
A. Drobyshev,
В. С. Комлев,
С И Рожков,
I. I. Eryomin,
I. G. Dalgatov,
Г. А. Воложин,
V. I. Grachyov,
A. Yu. Fedotov,
А. А. Исаев
Publication year - 2015
Publication title -
vestnik travmatologii i ortopedii imeni n.n. priorova
Language(s) - English
Resource type - Journals
eISSN - 2658-6738
pISSN - 0869-8678
DOI - 10.32414/0869-8678-2015-1-35-42
Subject(s) - octacalcium phosphate , regeneration (biology) , chemistry , gene , vascular endothelial growth factor , genetic enhancement , bone marrow , microbiology and biotechnology , materials science , biomedical engineering , anatomy , vegf receptors , biology , phosphate , medicine , biochemistry , cancer research , immunology
Gene-activated osteoplastic materials are a principally new class of medical devices for bone plasty. The purpose of the study was to evaluate the biological action of the material based on octacalcium phosphate and plasmid DNA containing vascular endothelial growth factor (VEGF) gene. Study material was implanted into 10 mm diameter rabbit parietal bone defects. Formation of bone regenerates around material granules even in the center of the defect and the presence of bone marrow in intertrabecular space on day 60 after implantation was detected. In control group of animals - implantation of carrier without gene constructions - regeneration took place mainly on the bone defect margins. Use of gene-activated osteoplastic material resulted in pronounced osteoinduction that provided both acceleration of the regeneration and increase of new bone tissue formation intensity.