Open AccessCharacteristics of humoral response in individual IgG subclasses in the course of selected bacterial infections in humans
Author(s) -
Waldemar Rastawicki
Publication year - 2018
Publication title -
medycyna doświadczalna i mikrobiologia
Language(s) - English
Resource type - Journals
eISSN - 2545-2517
pISSN - 0025-8601
DOI - 10.32394/mdm.70.2.11
Subject(s) - subclass , antigen , immunology , antibody , biology , antibody response , humoral immunity , immunoglobulin g , polysaccharide , microbiology and biotechnology , biochemistry
It has been recognized that human serum IgG is composed of four distinct subclasses. The IgG subclasses differ not only in their distribution in normal serum, but also in their biological properties and the nature of the antigens which elicit their production. In general, bacterial proteins antigens preferentially induce IgG1 antibodies in humans, with minor contributions of IgG3 and IgG4. In contrast, IgG response to polysaccharides is normally restricted to the IgG2 subclass, although some polysaccharides also induce substantial amounts of IgG1.