Open AccessMicrobial Transformation of Some Ethylpyridines by Fungi
Author(s) -
Igor A. Parshikov,
AUTHOR_ID
Publication year - 2022
Language(s) - English
Resource type - Reports
DOI - 10.32370/iaj.2635
Subject(s) - hydroxylation , pyridine , ring (chemistry) , biotransformation , chemistry , methylene , fungus , transformation (genetics) , nitrogen atom , beauveria bassiana , stereoselectivity , medicinal chemistry , nitrogen , organic chemistry , methyl group , stereochemistry , biochemistry , group (periodic table) , botany , biology , enzyme , gene , biological pest control , catalysis
We were observed transformation 4-ethylpyridine and 2-methyl-5-ethylpyridine by fungus Beauveria bassiana ATCC 7159. Stereoselective oxidation of methylene group leading to the optically active (-)-(1-hydroxyethyl)pyridine was shown. Besides, the hydroxylation of methyl groups and the oxidation of the heterocyclic ring in the nitrogen atom to the respective primary alcohols and N-oxides were observed