Open AccessAntimicrobial and antifungal properties of 4-((R-iden)amino)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol
Author(s) -
А. А. Сафонов,
Т. V. Panasenko,
Е. Г. Кныш,
Н. М. Поліщук
Publication year - 2019
Publication title -
farmacevtičnij žurnal/farmacevtičnij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2617-9628
pISSN - 0367-3057
DOI - 10.32352/0367-3057.2.15.02
Subject(s) - antimicrobial , thiophene , thiol , 1,2,4 triazole , chemistry , antifungal , fluconazole , combinatorial chemistry , triazole , organic chemistry , stereochemistry , microbiology and biotechnology , biology
For creating a new biologically active compounds are using a system on which already exist medications. One such system is the core of 1,2,4-triazole.
The aim of our work was to study the antimicrobial and antifungal activity new 4-((R-iden)amino)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiols. The study was conducted according to the method of serial dilutions.
As a result of studies new synthesized 4-((R-idene)amino)-5-(thiophene-2-ilmetyl)-4H-1,2,4-triazoles-3-thiols exhibit antimicrobial and antifungal activity.
The most active compound that exhibits antimicrobial activity against Staphylococcus aureus is 4-((1-(phenyl)ethylidene)amino)-5-(thiophene-2-ilmetyl)-4H-1,2,4-triazoles-3-thiol and 4-((3-nitrobenzylidene)amino)-5-(thiophene-2-ilmetyl)-4H-1,2,4-triazoles-3-thiol, 4-((4-fluorbenzylidene)amino)-5-(thiophene-2-ilmetyl)-4H-1,2,4-triazoles-3-thiol exhibit antifungal activity level of the comparator fluconazole, compound III, VI exceed its performance.