Open AccessTechnology administration active substance in the ointment base
Author(s) -
V. V. Trochimchuk,
V. V. Shmatenko,
В. О. Тарасенко,
А. О. Дроздова
Publication year - 2019
Publication title -
farmacevtičnij žurnal/farmacevtičnij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2617-9628
pISSN - 0367-3057
DOI - 10.32352/0367-3057.1.15.02
Subject(s) - ofloxacin , active ingredient , nimesulide , antimicrobial , pharmacology , chemistry , lidocaine , antibacterial activity , drug , chromatography , medicine , antibiotics , surgery , bacteria , ciprofloxacin , organic chemistry , biochemistry , biology , genetics
The problem of expanding the range of medicines that are used for the topical treatment of wound process, remains an important challenge for practical military medicine. In this aspect, there are topical ointments combining development for use in the first phase of wound process, which has a complex influence on the pathological processes and exhibits antibacterial, anti-inflammatory and local anesthetic activity.
The aim of the study was substantiation of technological route of administration of the active pharmaceutical ingredients in the ointment base, depending on the antimicrobial activity of model compositions.
The study included a model sample of ointment bases, cooked on a hydrophilic carrier containing active pharmaceutical ingredients – ofloxacin, nimesulide and lidocaine.
Microbiological studies were performed by difution on solid agar medium, which is based on the ability of substances to inhibit the growth antibakterial microorganisms.
Comparative analysis of experimental studies showed that the samples of ointments, which are based whith the active pharmaceutical ingredients ofloxacin, nimesulide and lidocaine was injected as a solution in DMSO showed the highest antimicrobial activity.
As a result of study on the antimicrobial activity of ointments model samples determined that the optimal method of administering the basis AFI – ofloxacin, nimesulide and lidocaine – a method of administering them in the form of a solution in DMSO.