Open AccessMORPHOLOGICAL CHANGES OF PITUITARY- ADRENAL SYSTEM OF RATS AFTER THERMAL INJURY
Author(s) -
Oleksandr Kovalchuk,
В. Г. Черкасов,
І. V. Dzevulska,
В. М. Титаренко,
О. В. Маліков
Publication year - 1970
Publication title -
ukraïnsʹkij naukovo-medičnij molodìžnij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2311-6951
pISSN - 1996-353X
DOI - 10.32345/usmyj.86(1).2015.10-16
Subject(s) - hemodynamics , microcirculation , medicine , hypoxia (environmental) , pathology , stromal cell , pathogenesis , necrosis , parenchyma , endocrinology , chemistry , organic chemistry , oxygen
Summary: on the experimental model of the local thermal bum we investigated reactive changes of the pituitary-adrenal system in rats. In burned rat installed nonspecific destructive changes parenchymal and stromal elements of the adenohypophysis and adrenal glands. Changes characterized three phases of the development of organ dysfunction: 1-3 days - microcirculatory disorders and degenerative changes of initiation; 7-14 day - the progression of degenerative changes and stabilization; 21- 30 day - activation of regenerative processes and hemodynamics. In the pathogenesis of burn injury leading place has regional hemodynamic changes. Microcirculation disturbance cause ischemic cell injury, development of dystrophic disorders and in critical hypoxia caused tissue necrosis.