THE REAEARCH OF TREATMENT ACTIVITY OF COMBINED COMPOSITION OF RECTAL CREAM ON THE MODEL OF THE CHRONIC ANAL FISSURE

Relevance. The development of a new pharmaceutical composition, in the form of a rectal cream containing diltiazem, lidocaine and methyluracil, for the conservative treatment of a chronic anal fissure (KAT) is scientifically substantiated. But by this time in Ukraine none of the above local medicines has been produced, which would be in line with the current pathogenetic concept of HAT therapy. Thus, the introduction of a new domestic medicinal product for the purpose of import substitution in this pharmaco-therapeutic group is an urgent task of the pharmacological science. Objective of the trial is to research the therapeutic effect of the rectal cream of the combined composition (RCCC) on the model of chronic anal fissure. Materials and methods. Chronic anal fissures were reproduced using the method of Adieva R.F. with co-authors. The research was performed on 48 white nonlinear rats. Evaluation of the therapeutic effect of the rectal cream and the comparator was carried out daily during the experiment based on criteria of severity of the pathological process and data macroscopic observations, hematological and morphological examination, as well as the integral index, considered the death rate of the animals. Results. The research allowed to determine that use of pharmaceutical composition which contains diltiazem, lidocaine and methyluracil in the experiment of chronic anal fissure leads to decreasing the severity of inflammation on 31 %, decreasing of the purulonecrotic complications on 57,1 % as well as improving the reparative processes of marginal epithelialization on 42,9 %. Conclusion. The therapeutic effect of the investigated cream is most likely caused its ability to decrease the tone of the muscle fibers of the internal anal sphincter, normalize the microcirculation and stimulate cell proliferation. It was also concluded that the comparator product "Proctosan" is inferior to the investigated cream on the effectiveness and practically does not show a therapeutic effect on the model of chronic anal fissure.