Open AccessBRAIN INJURY: MEDICO-SOCIAL AND SCIENTIFIC ASPECTS. Review
Author(s) -
С. В. Зябліцев,
T.I. Panova,
S. V. Kolesnikova,
О.V. Nahornyi
Publication year - 2020
Publication title -
medična nauka ukraïni
Language(s) - English
Resource type - Journals
eISSN - 2664-4738
pISSN - 2664-472X
DOI - 10.32345/2664-4738.1.2020.09
Subject(s) - traumatic brain injury , gliosis , neuroinflammation , neuroscience , disease , medicine , brain trauma , psychology , intensive care medicine , pathology , psychiatry
The review provides up-to-date data on the medico-social significance and scientific aspects of traumatic brain injury (TBI), in particular, the processes of neuroinflammation and the development of autoimmune reactions. According to the results of the analysis of open literature (PumMed database), it is established that among persons of working age, TBI holds the first place in the mortality structure, which is 2-3 times higher in Ukraine than similar indicators of economically developed countries. Each year, TBI costs the world economy about $ 400 billion, which is 0.5% of the gross world product. From a scientific point of view, TBI can be regarded as a continuous, possibly lifelong, process that affects multiple organ systems and can be a cause of traumatic disease. The main pathogenetic mechanisms of TBI that successively change each other (necrosis, axonal damage, gliosis/microgliosis, apoptosis, demyelinization and neuroregeneration) are highlighted.