MicroRNA-99b-5p targets mTOR/AR axis, induces autophagy and inhibits prostate cancer cell proliferation | Zendy

Suryakant K. Niture | Zendy; Lucas Tricoli | Zendy; Qi Qi | Zendy; Sashi Gadi | Zendy; Kala Hayes | Zendy; Deepak Kumar | Zendy

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MicroRNA-99b-5p targets mTOR/AR axis, induces autophagy and inhibits prostate cancer cell proliferation

Author(s) -

Suryakant K. Niture,

Lucas Tricoli,

Qi Qi,

Sashi Gadi,

Kala Hayes,

Deepak Kumar

Publication year - 2022

Publication title -

tumor biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.055

H-Index - 84

eISSN - 1423-0380

pISSN - 1010-4283

DOI - 10.3233/tub-211568

Subject(s) - autophagy , microrna , pi3k/akt/mtor pathway , prostate cancer , cell growth , cancer research , discovery and development of mtor inhibitors , cell , cancer , prostate , microbiology and biotechnology , biology , medicine , apoptosis , signal transduction , gene , genetics

MicroRNAs (miRNAs) are the small non-coding regulatory RNA molecules involved in gene regulation via base-pairing with complementary sequences in mRNAs. The dysregulation of specific miRNAs, such as miR-99b-5p (miR-99b), is associated with prostate cancer (PCa) progression. However, the mechanistic role of miR-99b in PCa remains to be determined. In this study, we aimed to investigate the functional and clinical significance of miR-99b in PCa.

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