Open AccessMicroRNA-99b-5p targets mTOR/AR axis, induces autophagy and inhibits prostate cancer cell proliferation
Author(s) -
Suryakant K. Niture,
Lucas Tricoli,
Qi Qi,
Sashi Gadi,
Kimberly Hayes,
Deepak Kumar
Publication year - 2022
Publication title -
tumor biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 84
eISSN - 1423-0380
pISSN - 1010-4283
DOI - 10.3233/tub-211568
Subject(s) - pi3k/akt/mtor pathway , microrna , lncap , cell growth , biology , prostate cancer , cancer research , gene expression , protein kinase b , microbiology and biotechnology , three prime untranslated region , untranslated region , autophagy , gene , rna , signal transduction , cancer , apoptosis , genetics
MicroRNAs (miRNAs) are the small non-coding regulatory RNA molecules involved in gene regulation via base-pairing with complementary sequences in mRNAs. The dysregulation of specific miRNAs, such as miR-99b-5p (miR-99b), is associated with prostate cancer (PCa) progression. However, the mechanistic role of miR-99b in PCa remains to be determined. In this study, we aimed to investigate the functional and clinical significance of miR-99b in PCa.