Open AccessComparison of hemodynamic changes after repetitive transcranial magnetic stimulation over the anatomical hand knob and hand motor hotspot: A functional near-infrared spectroscopy study
Author(s) -
Jinuk Kim,
Heegoo Kim,
Jungsoo Lee,
Hwang-Jae Lee,
Yoonju Na,
Won Hyuk Chang,
Yun-Hee Kim
Publication year - 2021
Publication title -
restorative neurology and neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.768
H-Index - 77
eISSN - 1878-3627
pISSN - 0922-6028
DOI - 10.3233/rnn-201032
Subject(s) - transcranial magnetic stimulation , motor cortex , stimulation , functional near infrared spectroscopy , psychology , lateralization of brain function , medicine , audiology , cerebral hemisphere , neuroscience , anesthesia , prefrontal cortex , cognition
Background: Low-frequency rTMS can induce upregulation of excitability in the contralateral hemisphere by interhemispheric interaction. Objective: The aim of this study was to compare the effects of interhemispheric modulation on hemodynamic changes after applying low-frequency rTMS over the anatomical hand knob (HK) and the hand motor hotspot (hMHS) in the dominant motor cortex. Methods: Ten healthy right-handed participants without a history of neurological or psychiatric symptoms (five males; 29.8±2.8 years) participated in this single-blind, randomized, cross-over study. rTMS was applied under three conditions over the dominant (left) hemisphere for 20 minutes: 1) 1 Hz rTMS stimulation on the HK (HK-rTMS), 2) 1 Hz rTMS stimulation on the hMHS (hMHS-rTMS), and 3) sham stimulation (Sham-rTMS). For all participants, functional near-infrared spectroscopy (fNIRS) was applied for measurement of cerebral oxyhemoglobin (oxyHb) and deoxyhemoglobin (deoxyHb) concentration over the non-dominant (right) hemisphere during a serial reaction time task (SRTT) with the non-dominant (left) hand before and after each condition. Results: The average coordinates of the hMHS (x = – 39.60 mm, y = – 17.11 mm, z = 66.40 mm) were anterior and lateral to the HK (x = – 36.72 mm, y = – 28.87 mm, z = 56.41 mm). In fNIRS time-series analysis, the integral value of oxyHb was significantly increased over the motor cortical region of the non-dominant hemisphere after the hMHS-rTMS compared with Sham-rTMS. The HK-rTMS also showed slight increment of oxyHb concentration but without statistical significance. The SPM group analysis showed greater magnitude of the activity in hMHS-rTMS than that of HK-rTMS after stimulation (p < 0.05). Conclusions: These results demonstrated an interhemispheric modulation effect of hemodynamic changes by 1 Hz rTMS. The hMHS produced a more robust modulation effect of 1 Hz rTMS on the contralateral hemisphere than did the HK. Therefore, the rTMS can be considered a better stimulation target than the HK.