Open AccessCytogenetic analysis in a large series of children with non-syndromic mental retardation
Author(s) -
Inesse Ben Abdallah Bouhjar,
Abir Gmidène,
Soumaya Mougou-Zrelli,
Hajer Hannachi,
Najla Soyah,
Naoufel Gadour,
Imed Harrabi,
Hatem Elghezal,
Ali Sarkhosh
Publication year - 2015
Publication title -
journal of pediatric genetics
Language(s) - English
Resource type - Journals
eISSN - 2146-4596
pISSN - 2146-460X
DOI - 10.3233/pge-2012-027
Subject(s) - etiology , medicine , pediatrics , cytogenetics , chromosomal analysis , congenital malformations , chromosome analysis , molecular cytogenetics , population , growth retardation , epilepsy , intellectual disability , karyotype , chromosome , psychiatry , genetics , biology , pregnancy , environmental health , gene
Mental retardation affects 1-3% of the population. To evaluate the implication of chromosomal abnormalities in the etiology of mental retardation, 1420 patients with non-syndromic mental retardation recruited at the department of cytogenetics of Farhat Hached hospital (Sousse, Tunisia) between January 2005 and December 2009, were analyzed using standard cytogenetic techniques. Age ranged between 3 and 18 years with a median of 8 years. Chromosomal abnormalities were detected in 7.8% of patients and an increased prevalence of chromosome anomalies was observed in patients when the mental retardation is associated with a severe degree of intellectual disability, facial dysmorphic features and/or congenital malformations or epilepsy.