Single nucleotide polymorphisms in the dual specificity phosphatase genes and risk of necrotizing enterocolitis in premature infant | Zendy

María Talavera | Zendy; Yan Jin | Zendy; E.J. Zmuda | Zendy; Julia-Stefanie Frick | Zendy; Yuying Liu | Zendy; Kim L. McBride | Zendy; LD Nelin | Zendy; Jennifer K. Trittmann | Zendy

Open Access

Single nucleotide polymorphisms in the dual specificity phosphatase genes and risk of necrotizing enterocolitis in premature infant

Author(s) -

María Talavera,

Yan Jin,

E.J. Zmuda,

Julia-Stefanie Frick,

Yuying Liu,

Kim L. McBride,

LD Nelin,

Jennifer K. Trittmann

Publication year - 2020

Publication title -

journal of neonatal-perinatal medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.444

H-Index - 17

eISSN - 1934-5798

pISSN - 1878-4429

DOI - 10.3233/npm-190302

Subject(s) - necrotizing enterocolitis , single nucleotide polymorphism , gene , biology , genetics , medicine , genotype

Differences in the susceptibility of preterm infants to develop necrotizing enterocolitis (NEC) implicate potential genetic differences in response to the inflammatory stimuli leading to NEC. Dual specificity phosphatases (DUSPs) are a key suppressor pathway of the mitogen-activated protein kinase (MAPK) pro-inflammatory signaling pathway. We hypothesized that inherited single nucleotide polymorphisms (SNPs) in DUSP genes contribute to NEC susceptibility in premature infants.

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