Open AccessSingle nucleotide polymorphisms in the dual specificity phosphatase genes and risk of necrotizing enterocolitis in premature infant
Author(s) -
Talavera Mm,
Yinghua Jin,
Zmuda Ej,
Jessica Frick,
Liu Y,
McBride Kl,
Nelin Ld,
Trittmann Jk
Publication year - 2020
Publication title -
journal of neonatal-perinatal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.444
H-Index - 17
eISSN - 1934-5798
pISSN - 1878-4429
DOI - 10.3233/npm-190302
Subject(s) - single nucleotide polymorphism , necrotizing enterocolitis , minor allele frequency , snp , odds ratio , allele , genotype , medicine , gene , snp array , biology , genetics
Differences in the susceptibility of preterm infants to develop necrotizing enterocolitis (NEC) implicate potential genetic differences in response to the inflammatory stimuli leading to NEC. Dual specificity phosphatases (DUSPs) are a key suppressor pathway of the mitogen-activated protein kinase (MAPK) pro-inflammatory signaling pathway. We hypothesized that inherited single nucleotide polymorphisms (SNPs) in DUSP genes contribute to NEC susceptibility in premature infants.