Open AccessSETD2 Regulates the Methylation of Translation Elongation Factor eEF1A1 in Clear Cell Renal Cell Carcinoma1
Author(s) -
Robert Hapke,
Lindsay Venton,
Kristie L. Rose,
Quanhu Sheng,
Anupama Reddy,
Rebecca Prather,
Angela L. Jones,
W. Kimryn Rathmell,
Scott M. Haake
Publication year - 2022
Publication title -
kidney cancer
Language(s) - English
Resource type - Journals
eISSN - 2468-4570
pISSN - 2468-4562
DOI - 10.3233/kca-220009
Subject(s) - histone methyltransferase , histone h3 , methylation , histone , biology , eukaryotic translation elongation factor 1 alpha 1 , translation (biology) , microbiology and biotechnology , methyltransferase , histone methylation , gene expression , cancer research , dna methylation , gene , genetics , rna , messenger rna , ribosome
SET domain-containing protein 2 ( SETD2 ) is commonly mutated in renal cell carcinoma. SETD2 methylates histone H3 as well as a growing list of non-histone proteins.