Open AccessThe proSAAS Chaperone Provides Neuroprotection and Attenuates Transsynaptic α-Synuclein Spread in Rodent Models of Parkinson’s Disease
Author(s) -
Iris Lindberg,
Shuie Zhan,
Hoa A. Lam,
Michael Helwig,
Nur Yucer,
Alex Laperle,
Clive N. Svendsen,
Donato A. Di Monte,
Nigel T. Maidment
Publication year - 2022
Publication title -
journal of parkinson's disease/journal of parkinson's disease (online)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.747
H-Index - 45
eISSN - 1877-718X
pISSN - 1877-7171
DOI - 10.3233/jpd-213053
Subject(s) - alpha synuclein , substantia nigra , parkinson's disease , neuroprotection , striatum , neuroscience , tyrosine hydroxylase , neurite , biology , midbrain , neurodegeneration , dopamine , dopaminergic , central nervous system , pathology , medicine , biochemistry , disease , in vitro
Parkinson's disease involves aberrant aggregation of the synaptic protein alpha-synuclein (aSyn) in the nigrostriatal tract. We have previously shown that proSAAS, a small neuronal chaperone, blocks aSyn-induced dopaminergic cytotoxicity in primary nigral cultures.