The proSAAS Chaperone Provides Neuroprotection and Attenuates Transsynaptic α-Synuclein Spread in Rodent Models of Parkinson’s Disease | Zendy

Iris Lindberg | Zendy; Zhan Shu | Zendy; Hoa A. Lam | Zendy; Michael Helwig | Zendy; Nur Yucer | Zendy; Alex Laperle | Zendy; Clive N. Svendsen | Zendy; Donato A. Di Monte | Zendy; Nigel T. Maidment | Zendy

Open Access

The proSAAS Chaperone Provides Neuroprotection and Attenuates Transsynaptic α-Synuclein Spread in Rodent Models of Parkinson’s Disease

Author(s) -

Iris Lindberg,

Zhan Shu,

Hoa A. Lam,

Michael Helwig,

Nur Yucer,

Alex Laperle,

Clive N. Svendsen,

Donato A. Di Monte,

Nigel T. Maidment

Publication year - 2022

Publication title -

journal of parkinson s disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.747

H-Index - 45

eISSN - 1877-718X

pISSN - 1877-7171

DOI - 10.3233/jpd-213053

Subject(s) - alpha synuclein , substantia nigra , parkinson's disease , neuroprotection , striatum , neuroscience , tyrosine hydroxylase , neurite , biology , midbrain , neurodegeneration , dopamine , dopaminergic , central nervous system , pathology , medicine , biochemistry , disease , in vitro

Parkinson's disease involves aberrant aggregation of the synaptic protein alpha-synuclein (aSyn) in the nigrostriatal tract. We have previously shown that proSAAS, a small neuronal chaperone, blocks aSyn-induced dopaminergic cytotoxicity in primary nigral cultures.

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