Open AccessA European Observational Study to Evaluate the Safety and the Effectiveness of Safinamide in Routine Clinical Practice: The SYNAPSES Trial
Author(s) -
Giovanni Abbruzzese,
Jaime Kulisevsky,
Bruno Bergmans,
Juan Carlos GómezEsteban,
Georg Kägi,
Jason Raw,
Alessandro Stefani,
Tobias Warnecke,
Wolfgang H. Jost
Publication year - 2021
Publication title -
journal of parkinson's disease/journal of parkinson's disease (online)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.747
H-Index - 45
eISSN - 1877-718X
pISSN - 1877-7171
DOI - 10.3233/jpd-202224
Subject(s) - medicine , adverse effect , observational study , cohort , cohort study , retrospective cohort study , clinical trial , population , pediatrics , environmental health
Safinamide modulates both dopaminergic and glutamatergic systems with positive effects on motor and non-motor symptoms of Parkinson's disease (PD). The drug utilization study SYNAPSES was designed to investigate the use of safinamide in routine clinical practice, as recommended by the European Medicines Agency.