Open AccessDoes Serum Urate Change as Parkinson’s Disease Progresses?
Author(s) -
Yasemin G Hasimoglu,
Xiqun Chen,
Rachit Bakshi,
Michael A. Schwarzschild,
Eric A. Macklin
Publication year - 2020
Publication title -
journal of parkinson's disease/journal of parkinson's disease (online)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.747
H-Index - 45
eISSN - 1877-718X
pISSN - 1877-7171
DOI - 10.3233/jpd-202064
Subject(s) - medicine , biomarker , disease , parkinson's disease , hyperuricemia , serum concentration , uric acid , stage (stratigraphy) , gastroenterology , endocrinology , chemistry , biochemistry , biology , paleontology
Higher serum urate concentration is associated with decreased risk of Parkinson's disease (PD) as well as slower disease progression, but its relationship with severity of PD remains unclear. This study investigated whether changes in serum urate concentration over 5 years were associated with disease progression assessed by MDS-UPDRS Part III score, Hoehn and Yahr stage, or DaTscan imaging. Average serum urate concentration was stable over time and change in serum urate concentration did not correlate with worsening of measures of PD progression. These results suggest that serum urate concentration is not a monitoring biomarker of PD progression in early stages.