Open AccessGlial cell-derived neurotrophic factor gene polymorphisms affect severity and functionality of bipolar disorder
Author(s) -
Roghaiyeh Safari,
Zeliha Tunca,
Ayşegül Özerdem,
Deniz Ceylan,
Yaprak Yılmaz Yalçın,
Meral Sakızlı
Publication year - 2018
Publication title -
journal of integrative neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.336
H-Index - 33
eISSN - 1757-448X
pISSN - 0219-6352
DOI - 10.3233/jin-170031
Subject(s) - glial cell line derived neurotrophic factor , single nucleotide polymorphism , bipolar disorder , neurotrophic factors , snp , global assessment of functioning , genotype , medicine , clinical global impression , psychology , oncology , bioinformatics , biology , gene , genetics , pathology , lithium (medication) , receptor , body mass index , alternative medicine , placebo
Glial cell-derived neurotrophic factor and other neurotrophins have important role in the development of mental disorders. Here, we aimed to assess the effects of Single nucleotide polymorphisms at potentially regulated regions of GDNF on severity and functionality of bipolar disorder and GDNF serum levels in bipolar disorder patients and healthy volunteers. Severity and functionality of bipolar disorder were evaluated using the Clinical Global Impression and Global Assessment of Functioning scales in sixty-six bipolar disorder patients. The GDNF serum levels obtained from bipolar disorder patients and healthy volunteers who had been already reported SNPs information by our group. GAF scales were lower and GDNF serum levels were higher in Bipolar disorder patients with T/A genotype at 5:37812784 and 5:37812782 compared to patients with T/T genotype. There were significant difference in severity and functionality scores, but not in GDNF serum levels, between patients with G/G and G/A genotype of rs62360370 G > A SNP.rs2075680 C > A and rs79669773 T > C SNPs had no effect on bipolar disorder severity and functionality scores and GDNF serum levels. The results suggest that some SNPs of GDNF have potential association with severity and functionality of bipolar disorder. In addition, except two SNPs, none of GDNF SNPs had association with GDNF serum levels.