Open AccessStriatal Cholesterol Precursors Are Altered with Age in Female Huntington’s Disease Model Mice
Author(s) -
Anna C Pfalzer,
Phillip A. Wages,
Ned A. Porter,
Aaron B. Bowman
Publication year - 2019
Publication title -
journal of huntington's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.081
H-Index - 24
eISSN - 1879-6400
pISSN - 1879-6397
DOI - 10.3233/jhd-180321
Subject(s) - huntington's disease , cholesterol , disease , medicine , huntingtin , neuroscience , striatum , psychology , endocrinology , dopamine
Cholesterol is necessary for proper neurodevelopment and neuronal health. The brain relies on neural and astrocytic de novo cholesterol synthesis. Huntington's disease presents with altered levels of cholesterol precursors however it is unknown when the disruption in this molecular pathway occurs and whether Manganese (Mn) may alter these metabolic alterations.