In Vivo MRI Evidence that Neuropathology is Attenuated by Cognitive Enrichment in the Yac128 Huntington’s Disease Mouse Model | Zendy

Jessica J. Steventon | Zendy; David J. Harrison | Zendy; Rebecca C. Trueman | Zendy; Anne Rosser | Zendy; Derek K. Jones | Zendy; Simon P. Brooks | Zendy

Open Access

In Vivo MRI Evidence that Neuropathology is Attenuated by Cognitive Enrichment in the Yac128 Huntington’s Disease Mouse Model

Author(s) -

Jessica J. Steventon,

David J. Harrison,

Rebecca C. Trueman,

Anne Rosser,

Derek K. Jones,

Simon P. Brooks

Publication year - 2015

Publication title -

journal of huntington s disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.081

H-Index - 24

eISSN - 1879-6400

pISSN - 1879-6397

DOI - 10.3233/jhd-150147

Subject(s) - neuropathology , in vivo , cognition , huntington's disease , neuroscience , magnetic resonance imaging , psychology , genetically modified mouse , putamen , environmental enrichment , atrophy , pathology , medicine , disease , transgene , biology , radiology , biochemistry , microbiology and biotechnology , gene

Environmental enrichment has been shown to improve symptoms and reduce neuropathology in mouse models of Huntington's disease (HD); however results are limited to ex vivo techniques with associated shortcomings. In-vivo magnetic resonance imaging (MRI) can overcome some of the shortcomings and is applied for the first time here to assess the effect of a cognitive intervention in a mouse model of HD.

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