Open AccessIn Vivo MRI Evidence that Neuropathology is Attenuated by Cognitive Enrichment in the Yac128 Huntington’s Disease Mouse Model
Author(s) -
Jessica J Steventon,
David J. Harrison,
Rebecca C. Trueman,
Anne Elizabeth Rosser,
Derek K. Jones,
Simon Philip Brooks
Publication year - 2015
Publication title -
journal of huntington's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.081
H-Index - 24
eISSN - 1879-6400
pISSN - 1879-6397
DOI - 10.3233/jhd-150147
Subject(s) - neuropathology , in vivo , cognition , huntington's disease , neuroscience , magnetic resonance imaging , psychology , genetically modified mouse , putamen , environmental enrichment , atrophy , pathology , medicine , disease , transgene , biology , radiology , biochemistry , microbiology and biotechnology , gene
Environmental enrichment has been shown to improve symptoms and reduce neuropathology in mouse models of Huntington's disease (HD); however results are limited to ex vivo techniques with associated shortcomings. In-vivo magnetic resonance imaging (MRI) can overcome some of the shortcomings and is applied for the first time here to assess the effect of a cognitive intervention in a mouse model of HD.