Open AccessMaqui, Calafate, and Blueberry fruits extracts treatments suppress the pathogenic interaction amongst human adipocytes and macrophages
Author(s) -
Angelica Ovalle-Marin,
Marjorie Reyes-Farías,
Karla Vásquez,
Claudia Parra-Ruiz,
Vilma Quitral,
Paula Jiménez,
Lorena Garcı́a,
Leslie Ramírez,
Javier Quezada,
Pedro GonzálezMuniesa,
Diego F. García-Díaz
Publication year - 2020
Publication title -
journal of berry research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.464
H-Index - 25
eISSN - 1878-5123
pISSN - 1878-5093
DOI - 10.3233/jbr-200576
Subject(s) - oxidative stress , adipose tissue , apoptosis , vaccinium , inflammation , antioxidant , biology , lipopolysaccharide , chemistry , pharmacology , endocrinology , biochemistry , immunology , botany
BACKGROUND: Obesity occurs due to a positive energy imbalance, leading to the expansion of adipose tissue. This phenomenon triggers a chronic low-grade inflammatory state, which is associated with comorbidities development. It is, therefore, of great interest to investigate new counteracting nutritional strategies. In this regard, polyphenol-rich Chilean native fruits, Aristotelia chilensis (Maqui) and Berberis microphylla (Calafate), and also the non-Chilean Vaccinium corymbosum (Blueberry), have been associated with antioxidant and anti-inflammatory features. OBJECTIVE: To evaluate Maqui, Calafate, and Blueberry aqueous extracts treatments on the pathogenic response of human activated macrophages and visceral adipocytes. METHODS: THP-1 monocyte human cell line and differentiated human visceral preadipocytes were activated (with lipopolysaccharide and TNF-α, for 48 and 24 h, respectively), and treated with the aqueous extracts. Inflammation and oxidative stress markers were assessed. RESULTS: Lower NO and IL-6 secretion, and inhibited apoptosis in activated macrophages, were observed. Also, decreased gene expression of MCP-1 and secretion of IL-6, inhibited apoptosis, and increased levels of GSH in activated adipocytes were detected. CONCLUSIONS: Maqui, Calafate, and Blueberry extracts showed anti-inflammatory and antioxidant responses in human macrophages and adipocytes.