Open AccessThe Biological Substrate of the Motoric Cognitive Risk Syndrome: A Pilot Study Using Amyloid-/Tau-PET and MR Imaging
Author(s) -
Giulia Bommarito,
Valentina Garibotto,
Giovanni B. Frisoni,
Federica Ribaldi,
Sara Stampacchia,
Frédéric Assal,
Stéphane Armand,
Gilles Allali,
Alessandra Griffa
Publication year - 2022
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-215461
Subject(s) - hyperintensity , diffusion mri , white matter , medicine , atrophy , cardiology , magnetic resonance imaging , nuclear medicine , pathology , radiology
A cross-sectional pilot study to explore the biological substrate of the Motoric Cognitive Risk (MCR) syndrome in a Memory Clinic cohort, using a multimodal imaging approach, was conducted. Twenty participants were recruited and classified as MCR+/−. Amyloid- and tau-PET uptakes, temporal atrophy, white matter hyperintensities, lateral ventricular volume (LVV), and diffusion tensor parameters were compared between groups. No significant differences were found in imaging features related to Alzheimer’s disease or gross vascular damage. MCR+ patients had increased LVV and altered diffusion parameters in the superior corona radiata. Ventricular enlargement and microstructural damage of the surrounding white matter tracts could contribute to MCR pathophysiology.