Characterization of Early Alzheimer’s Disease-Like Pathological Alterations in Non-Human Primates with Aging: A Pilot Study | Zendy

Hannah M. Jester | Zendy; Saahj P. Gosrani | Zendy; Huiping Ding | Zendy; Xueyan Zhou | Zendy; MeiChuan Ko | Zendy; Tao Ma | Zendy

Open Access

Characterization of Early Alzheimer’s Disease-Like Pathological Alterations in Non-Human Primates with Aging: A Pilot Study

Author(s) -

Hannah M. Jester,

Saahj P. Gosrani,

Huiping Ding,

Xueyan Zhou,

MeiChuan Ko,

Tao Ma

Publication year - 2022

Publication title -

journal of alzheimer s disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.677

H-Index - 139

eISSN - 1875-8908

pISSN - 1387-2877

DOI - 10.3233/jad-215303

Subject(s) - pathological , neuroscience , hippocampus , psychology , hyperphosphorylation , hippocampal formation , disease , prefrontal cortex , neurodegeneration , medicine , biology , pathology , kinase , cognition , microbiology and biotechnology

Sporadic or late onset Alzheimer's disease (LOAD) is a multifactorial neurodegenerative disease with aging the most known risk factor. Non-human primates (NHPs) may serve as an excellent model to study LOAD because of their close similarity to humans in many aspects including neuroanatomy and neurodevelopment. Recent studies reveal AD-like pathology in old NHPs.

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