Open AccessCharacterization of Early Alzheimer’s Disease-Like Pathological Alterations in Non-Human Primates with Aging: A Pilot Study
Author(s) -
Hannah M. Jester,
Saahj P. Gosrani,
Huiping Ding,
Xueyan Zhou,
MeiChuan Ko,
Tao Ma
Publication year - 2022
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-215303
Subject(s) - pathological , neuroscience , hippocampus , psychology , hyperphosphorylation , hippocampal formation , disease , prefrontal cortex , neurodegeneration , medicine , biology , pathology , kinase , cognition , microbiology and biotechnology
Sporadic or late onset Alzheimer's disease (LOAD) is a multifactorial neurodegenerative disease with aging the most known risk factor. Non-human primates (NHPs) may serve as an excellent model to study LOAD because of their close similarity to humans in many aspects including neuroanatomy and neurodevelopment. Recent studies reveal AD-like pathology in old NHPs.