Open AccessMitochondrial Membrane Potential Influences Amyloid-β Protein Precursor Localization and Amyloid-β Secretion
Author(s) -
Heather Wilkins,
Benjamin R Troutwine,
Blaise Menta,
Sharon Manley,
Taylor A. Strope,
Colton R Lysaker,
Russell H. Swerdlow
Publication year - 2022
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-215280
Subject(s) - mitochondrion , secretion , microbiology and biotechnology , biology , mitochondrial apoptosis induced channel , amyloid precursor protein , extracellular , organelle , mitochondrial fusion , inner mitochondrial membrane , alzheimer's disease , biochemistry , mitochondrial dna , medicine , disease , gene
Amyloid-β (Aβ), which derives from the amyloid-β protein precursor (AβPP), forms plaques and serves as a fluid biomarker in Alzheimer's disease (AD). How Aβ forms from AβPP is known, but questions relating to AβPP and Aβ biology remain unanswered. AD patients show mitochondrial dysfunction, and an Aβ/AβPP mitochondria relationship exists.