Open AccessMitochondrial Fusion Suppresses Tau Pathology-Induced Neurodegeneration and Cognitive Decline
Author(s) -
Gaofeng Wang,
Mengyu Liu,
Ju Gao,
Amber M. Smith,
Hisashi Fujioka,
Jingjing Liang,
George Perry,
Xinglong Wang
Publication year - 2021
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-215175
Subject(s) - tauopathy , neurodegeneration , mfn2 , cognitive decline , morris water navigation task , alzheimer's disease , tau protein , pathology , genetically modified mouse , gliosis , biology , neuroscience , medicine , mitochondrial fusion , hippocampus , transgene , dementia , biochemistry , disease , mitochondrial dna , gene
Abnormalities of mitochondrial fission and fusion, dynamic processes known to be essential for various aspects of mitochondrial function, have repeatedly been reported to be altered in Alzheimer's disease (AD). Neurofibrillary tangles are known as a hallmark feature of AD and are commonly considered a likely cause of neurodegeneration in this devastating disease.