Open AccessGene-Specific DNA Methylation Linked to Postoperative Cognitive Dysfunction in Apolipoprotein E3 and E4 Mice
Author(s) -
Katie J. Schenning,
Sarah Holden,
Brett A. Davis,
Amelia Mulford,
Kimberly A. Nevonen,
Joseph F. Quinn,
Jacob Raber,
Lucia Carbone,
Nabil J. Alkayed
Publication year - 2021
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-210499
Subject(s) - postoperative cognitive dysfunction , neurocognitive , dna methylation , epigenetics , isoflurane , apolipoprotein e , medicine , cognitive decline , cognition , bioinformatics , anesthesia , gene , disease , dementia , psychiatry , biology , genetics , gene expression
Geriatric surgical patients are at higher risk of developing postoperative neurocognitive disorders (NCD) than younger patients. The specific mechanisms underlying postoperative NCD remain unknown, but they have been linked to genetic risk factors, such as the presence of APOE4, compared to APOE3, and epigenetic modifications caused by exposure to anesthesia and surgery.