Open AccessAutophagy Induction and Accumulation of Phosphorylated Tau in the Hippocampus and Prefrontal Cortex of Adult C57BL/6 Mice Subjected to Adolescent Fluoxetine Treatment
Author(s) -
Jorge A. Sierra-Fonseca,
Minerva Rodriguez,
Anapaula Themann,
Omar Lira,
Francisco J. Flores-Ramirez,
Javier VargasMedrano,
Bharathi S. Gadad,
Sergio D. Iñiguez
Publication year - 2021
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-210475
Subject(s) - prefrontal cortex , hippocampus , autophagy , mood disorders , endocrinology , fluoxetine , medicine , neuroscience , hippocampal formation , psychology , biology , serotonin , psychiatry , receptor , cognition , genetics , apoptosis , anxiety
Fluoxetine (FLX) represents the antidepressant of choice for the management of pediatric mood-related illnesses. Accumulating preclinical evidence suggests that ontogenic FLX exposure leads to deregulated affect-related phenotypes in adulthood. Mood-related symptomatology constitutes a risk-factor for various neurological disorders, including Alzheimer's disease (AD), making it possible for juvenile FLX history to exacerbate the development of neurodegenerative diseases.