Open AccessUpregulation of Local Hepcidin Contributes to Iron Accumulation in Alzheimer’s Disease Brains
Author(s) -
Suman Chaudhary,
Ajay Ashok,
Dallas McDonald,
Aaron Wise,
Alexander E Kritikos,
Neil Rana,
Clifford V. Harding,
Neena Singh
Publication year - 2021
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-210221
Subject(s) - hepcidin , downregulation and upregulation , ferroportin , ferritin , alzheimer's disease , dementia , endocrinology , medicine , biology , disease , anemia , biochemistry , gene
Accumulation of iron is a consistent feature of Alzheimer's disease (AD) brains. The underlying cause, however, remains debatable.