Open AccessUnique Sleep and Circadian Rhythm Dysfunction Neuroinflammatory and Immune Profiles in Alzheimer’s Disease with Mild Cognitive Impairment
Author(s) -
Jagan A. Pillai,
James Bena,
Lynn M. Bekris,
Nancy FoldvarySchaefer,
Catherine Heinzinger,
Sujata Rao,
Stephen M. Rao,
James B. Leverenz,
Reena Mehra
Publication year - 2021
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-201573
Subject(s) - circadian rhythm , neurodegeneration , medicine , alzheimer's disease , neuroinflammation , inflammation , immune system , pathophysiology , cognitive decline , disease , neuroscience , cerebrospinal fluid , psychology , immunology , dementia
Sleep dysfunction has been identified in the pathophysiology of Alzheimer's disease (AD); however, the role and mechanism of circadian rhythm dysfunction is less well understood. In a well-characterized cohort of patients with AD at the mild cognitive impairment stage (MCI-AD), we identify that circadian rhythm irregularities were accompanied by altered humoral immune responses detected in both the cerebrospinal fluid and plasma as well as alterations of cerebrospinal fluid biomarkers of neurodegeneration. On the other hand, sleep disruption was more so associated with abnormalities in circulating markers of immunity and inflammation and decrements in cognition.