Open AccessSensitive Measures of Cognition in Mild Cognitive Impairment
Author(s) -
Nathaniel Klooster,
Stacey Humphries,
Eileen R. Cardillo,
Franziska Hartung,
Lin Xie,
Sandhitsu R. Das,
Paul A. Yushkevich,
Arun Pilania,
Jieqiong Wang,
David A. Wolk,
Anjan Chatterjee
Publication year - 2021
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-201280
Subject(s) - psychology , perirhinal cortex , cognition , semantic memory , cognitive psychology , neuropsychology , literal and figurative language , neuroscience , recognition memory , linguistics , philosophy
Sensitive measures of cognition are needed in preclinical and prodromal Alzheimer's disease (AD) to track cognitive change and evaluate potential interventions. Neurofibrillary tangle pathology in AD is first observed in Brodmann Area 35 (BA35), the medial portion of the perirhinal cortex. The importance of the perirhinal cortex for semantic memory may explain early impairments of semantics in preclinical AD. Additionally, our research has tied figurative language impairment to neurodegenerative disease.