Variation in VKORC1 Is Associated with Vascular Dementia | Zendy

Jure Mur | Zendy; Daniel L. McCartney | Zendy; Daniel I. Chasman | Zendy; Peter M. Visscher | Zendy; Graciela MuñizTerrera | Zendy; Simon R. Cox | Zendy; Tom C. Russ | Zendy; Riccardo E. Marioni | Zendy

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Variation in VKORC1 Is Associated with Vascular Dementia

Author(s) -

Jure Mur,

Daniel L. McCartney,

Daniel I. Chasman,

Peter M. Visscher,

Graciela MuñizTerrera,

Simon R. Cox,

Tom C. Russ,

Riccardo E. Marioni

Publication year - 2021

Publication title -

journal of alzheimer s disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.677

H-Index - 139

eISSN - 1875-8908

pISSN - 1387-2877

DOI - 10.3233/jad-201256

Subject(s) - variation (astronomy) , dementia , vascular dementia , medicine , disease , astrophysics , physics

The genetic variant rs9923231 (VKORC1) is associated with differences in the coagulation of blood and consequentially with sensitivity to the drug warfarin. Variation in VKORC1 has been linked in a gene-based test to dementia/Alzheimer's disease in the parents of participants, with suggestive evidence for an association for rs9923231 (p = 1.8×10-7), which was included in the genome-wide significant KAT8 locus.

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