Open AccessVariation in VKORC1 Is Associated with Vascular Dementia
Author(s) -
Jure Mur,
Daniel L. McCartney,
Daniel I. Chasman,
Peter M. Visscher,
Graciela MuñizTerrera,
Simon R. Cox,
Tom C. Russ,
Riccardo E. Marioni
Publication year - 2021
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-201256
Subject(s) - dementia , vascular dementia , medicine , warfarin , diabetes mellitus , allele , vkorc1 , stroke (engine) , atrial fibrillation , disease , endocrinology , genetics , biology , gene , cyp2c9 , mechanical engineering , cytochrome p450 , metabolism , engineering
The genetic variant rs9923231 (VKORC1) is associated with differences in the coagulation of blood and consequentially with sensitivity to the drug warfarin. Variation in VKORC1 has been linked in a gene-based test to dementia/Alzheimer's disease in the parents of participants, with suggestive evidence for an association for rs9923231 (p = 1.8×10-7), which was included in the genome-wide significant KAT8 locus.