Open AccessAPOE E2/E2 Is Associated with Slower Rate of Cognitive Decline with Age
Author(s) -
Benjamin Sweigart,
Stacy Andersen,
Anastasia Gurinovich,
Stephanie Cosentino,
Nicole Schupf,
Thomas Perls,
Paola Sebastiani
Publication year - 2021
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-201205
Subject(s) - apolipoprotein e , cognitive decline , genotype , longitudinal study , cognition , confounding , allele , demography , psychology , tics , medicine , gerontology , biology , genetics , dementia , psychiatry , disease , gene , pathology , sociology
The E4 allele of the APOE gene is known to be associated with cognitive impairment. However, a limited number of studies have examined the association between the E2 allele and longitudinal changes of cognitive function.