Open AccessGenetic Factors of Alzheimer’s Disease Modulate How Diet is Associated with Long-Term Cognitive Trajectories: A UK Biobank Study
Author(s) -
Brandon S. Klinedinst,
Scott T. Le,
Brittany Larsen,
Colleen Pappas,
Nathan Hoth,
Amy Pollpeter,
Qian Wang,
Yueying Wang,
Yu Shi,
Li Wang,
Karin Allenspach,
Jonathan P. Mochel,
David A. Bennett,
Auriel A. Willette
Publication year - 2020
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-201058
Subject(s) - cognitive decline , biobank , meal , cognition , disease , medicine , gerontology , demography , alzheimer's disease , family history , effects of sleep deprivation on cognitive performance , psychology , dementia , biology , bioinformatics , psychiatry , sociology
Fluid intelligence (FI) involves abstract problem-solving without prior knowledge. Greater age-related FI decline increases Alzheimer's disease (AD) risk, and recent studies suggest that certain dietary regimens may influence rates of decline. However, it is uncertain how long-term food consumption affects FI among adults with or without familial history of AD (FH) or APOE4 (ɛ4).