OGA Inhibition Alters Energetics and Nutrient Sensing in Alzheimer’s Disease Cytoplasmic Hybrids | Zendy

Jarrod Flax | Zendy; Heather Wilkins | Zendy; Reegan Miller | Zendy; Sarah Griffith | Zendy; Gentry K. Cork | Zendy; Amy Qiang | Zendy; Jeffrey Thompson | Zendy; Russell H. Swerdlow | Zendy; Chad Slawson | Zendy

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OGA Inhibition Alters Energetics and Nutrient Sensing in Alzheimer’s Disease Cytoplasmic Hybrids

Author(s) -

Jarrod Flax,

Heather Wilkins,

Reegan Miller,

Sarah Griffith,

Gentry K. Cork,

Amy Qiang,

Jeffrey Thompson,

Russell H. Swerdlow,

Chad Slawson

Publication year - 2020

Publication title -

journal of alzheimer s disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.677

H-Index - 139

eISSN - 1875-8908

pISSN - 1387-2877

DOI - 10.3233/jad-200996

Subject(s) - mitochondrion , bioenergetics , microbiology and biotechnology , cytoplasm , cell culture , biology , nutrient sensing , sirtuin , cell , biochemistry , enzyme , signal transduction , genetics , nad+ kinase

Alzheimer's disease (AD) features reductions in key bioenergetic fluxes and perturbed mitochondrial function. Cytoplasmic hybrids (cybrids) generated through the transfer of AD subject mitochondria to mtDNA-depleted SH-SY5Y neuroblastoma cells recapitulate some of these features in an in vitro setting.

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