Open AccessOGA Inhibition Alters Energetics and Nutrient Sensing in Alzheimer’s Disease Cytoplasmic Hybrids
Author(s) -
Jarrod Flax,
Heather Wilkins,
Reegan Miller,
Sarah M. Griffith,
Gentry K. Cork,
Amy Qiang,
Jeffrey Thompson,
Russell H. Swerdlow,
Chad Slawson
Publication year - 2020
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-200996
Subject(s) - mitochondrion , bioenergetics , microbiology and biotechnology , cytoplasm , cell culture , biology , nutrient sensing , sirtuin , cell , biochemistry , enzyme , signal transduction , genetics , nad+ kinase
Alzheimer's disease (AD) features reductions in key bioenergetic fluxes and perturbed mitochondrial function. Cytoplasmic hybrids (cybrids) generated through the transfer of AD subject mitochondria to mtDNA-depleted SH-SY5Y neuroblastoma cells recapitulate some of these features in an in vitro setting.