Open AccessEfficacy and Safety of Zonisamide in Dementia with Lewy Bodies Patients with Parkinsonism: A Post Hoc Analysis of Two Randomized, Double-Blind, Placebo-Controlled Trials
Author(s) -
Kazuko Hasegawa,
Kenji Kochi,
Hidenori Maruyama,
Osamu Konishi,
Shunji Toya,
Toshinari Odawara
Publication year - 2021
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-200893
Subject(s) - zonisamide , parkinsonism , dementia with lewy bodies , placebo , medicine , adverse effect , randomized controlled trial , clinical trial , dementia , psychology , psychiatry , disease , epilepsy , alternative medicine , pathology , topiramate
Although previous phase II and III clinical trials conducted in Japan showed that zonisamide improved parkinsonism in patients with dementia with Lewy bodies (DLB), some differences in efficacy outcomes were observed between the trials.