Open AccessExamining Sex Differences in Markers of Cognition and Neurodegeneration in Autosomal Dominant Alzheimer’s Disease: Preliminary Findings from the Colombian Alzheimer’s Prevention Initiative Biomarker Study
Author(s) -
Clara VilaCastelar,
Edmarie Guzmán-Vélez,
Enmanuelle PardillaDelgado,
Rachel F. Buckley,
Yamile Bocanegra,
Ana Baena,
Joshua T FoxFuller,
Victoria Tirado,
Claudia Muñoz,
Margarita Giraldo,
Natalia AcostaBaena,
Silvia RíosRomenets,
Jessica B. Langbaum,
Pierre N. Tariot,
Francisco Lopera,
Eric M. Reiman,
Yakeel T. Quiroz
Publication year - 2020
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-200723
Subject(s) - dementia , california verbal learning test , alzheimer's disease , verbal learning , psychology , cognition , disease , verbal memory , neurodegeneration , audiology , medicine , gerontology , neuroscience
Growing evidence suggests that there may be a sex-specific biological risk for Alzheimer's disease (AD). Individuals with autosomal dominant AD due to a mutation (E280A) in Presenilin-1 (PSEN1) are genetically determined to develop early-onset dementia and thus, have few age-related risk factors for AD that are known to vary by sex (i.e., cardiovascular disease, menopause, life expectancy).