Open AccessAutomated Hippocampal Subfield Volumetric Analyses in Atypical Alzheimer’s Disease
Author(s) -
Musa Nur Gabere,
Nha Trang Thu Pham,
Jonathan GraffRadford,
Mary M. Machulda,
Joseph R. Duffy,
Keith A. Josephs,
Jennifer L. Whitwell,
for Alzheimer’s Disease Neuroimaging Initiative
Publication year - 2020
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-200625
Subject(s) - subiculum , hippocampal formation , atrophy , dentate gyrus , hippocampus , entorhinal cortex , neuroscience , neocortex , pathology , temporal lobe , psychology , medicine , epilepsy
Posterior cortical atrophy (PCA) and logopenic progressive aphasia (LPA) are two of the most common variants of atypical Alzheimer's disease (AD). Both PCA and LPA are associated with relative sparing of hippocampus compared to neocortex, although hippocampal atrophy is observed. It is unclear whether regional patterns of hippocampal subfield involvement differ between PCA and LPA, and whether they differ from typical AD.