The Differential Influence of Immune, Endocytotic, and Lipid Metabolism Genes on Amyloid Deposition and Neurodegeneration in Subjects at Risk of Alzheimer’s Disease | Zendy

Grazia Daniela Femminella | Zendy; Denise Harold | Zendy; James A. Scott | Zendy; Julie Williams | Zendy; Paul Edison | Zendy

Open Access

The Differential Influence of Immune, Endocytotic, and Lipid Metabolism Genes on Amyloid Deposition and Neurodegeneration in Subjects at Risk of Alzheimer’s Disease

Author(s) -

Grazia Daniela Femminella,

Denise Harold,

James A. Scott,

Julie Williams,

Paul Edison

Publication year - 2020

Publication title -

journal of alzheimer s disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.677

H-Index - 139

eISSN - 1875-8908

pISSN - 1387-2877

DOI - 10.3233/jad-200578

Subject(s) - neurodegeneration , disease , immune system , amyloid (mycology) , lipid metabolism , alzheimer's disease , biology , neuroscience , medicine , immunology , pathology , biochemistry

Over 20 single-nucleotide polymorphisms (SNPs) are associated with increased risk of Alzheimer's disease (AD). We categorized these loci into immunity, lipid metabolism, and endocytosis pathways, and associated the polygenic risk scores (PRS) calculated, with AD biomarkers in mild cognitive impairment (MCI) subjects.

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