Open AccessRegional Hypoperfusion Predicts Decline in Everyday Functioning at Three-Year Follow-Up in Older Adults without Dementia
Author(s) -
Danielle L Sanchez,
Kelsey R. Thomas,
Emily C. Edmonds,
Mark W. Bondi,
Katherine J. Bangen,
Alzheimer’s Disease Neuroimaging Initiative
Publication year - 2020
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-200490
Subject(s) - dementia , psychology , gerontology , cerebral hypoperfusion , medicine , clinical psychology , perfusion , cardiology , disease
Increasing evidence indicates that cerebrovascular dysfunction may precede cognitive decline in aging and Alzheimer's disease (AD). Reduced cerebral blood flow (CBF) is associated with cognitive impairment in older adults. However, less is known regarding the association between CBF and functional decline, and whether CBF predicts functional decline beyond cerebrovascular and metabolic risk factors.