Open AccessMitochondrial DNA Manipulations Affect Tau Oligomerization
Author(s) -
Ian Weidling,
Heather Wilkins,
Scott J. Koppel,
Lewis Hutfles,
Xiaowan Wang,
Anuradha Kalani,
Blaise Menta,
Benjamin Ryan,
Judit Perez-Ortiz,
T. Chris Gamblin,
Russell H. Swerdlow
Publication year - 2020
Publication title -
journal of alzheimer's disease
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-200286
Subject(s) - mitochondrial dna , oligomer , mitochondrion , ethidium bromide , cytoplasm , biology , microbiology and biotechnology , cytochrome c oxidase , dna , chemistry , biochemistry , gene , organic chemistry
Mitochondrial dysfunction and tau aggregation occur in Alzheimer's disease (AD), and exposing cells or rodents to mitochondrial toxins alters their tau.