Open AccessCharacterizing Clinical and Neuropathological Traits of APOE Haplotypes in African Americans and Europeans
Author(s) -
Aziz M. Mezlini,
Colin Magdamo,
Emily Merrill,
Lori B. Chibnik,
Deborah Blacker,
Bradley T. Hyman,
Sudeshna Das
Publication year - 2020
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-200228
Subject(s) - haplotype , apolipoprotein e , dementia , allele , odds ratio , genotype , alzheimer's disease , disease , cohort , locus (genetics) , population , gerontology , demography , medicine , genetics , biology , gene , sociology
The APOEɛ4 allele is the largest genetic risk factor for late-onset Alzheimer's disease (AD). Recent literature suggested that the contribution of APOEɛ4 to AD risk could be population-specific, with ɛ4 conferring a lower risk to Blacks or African Americans.