Characterizing Clinical and Neuropathological Traits of APOE Haplotypes in African Americans and Europeans | Zendy

Aziz M. Mezlini | Zendy; Colin Magdamo | Zendy; Emily Merrill | Zendy; Lori B. Chibnik | Zendy; Deborah Blacker | Zendy; Bradley T. Hyman | Zendy; Sudeshna Das | Zendy

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Characterizing Clinical and Neuropathological Traits of APOE Haplotypes in African Americans and Europeans

Author(s) -

Aziz M. Mezlini,

Colin Magdamo,

Emily Merrill,

Lori B. Chibnik,

Deborah Blacker,

Bradley T. Hyman,

Sudeshna Das

Publication year - 2020

Publication title -

journal of alzheimer s disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.677

H-Index - 139

eISSN - 1875-8908

pISSN - 1387-2877

DOI - 10.3233/jad-200228

Subject(s) - haplotype , apolipoprotein e , dementia , allele , odds ratio , genotype , alzheimer's disease , disease , cohort , locus (genetics) , population , gerontology , demography , medicine , genetics , biology , gene , sociology

The APOEɛ4 allele is the largest genetic risk factor for late-onset Alzheimer's disease (AD). Recent literature suggested that the contribution of APOEɛ4 to AD risk could be population-specific, with ɛ4 conferring a lower risk to Blacks or African Americans.

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