Open AccessProfiles of Cognitive Change in Preclinical and Prodromal Alzheimer’s Disease Using Change-Point Analysis
Author(s) -
Owen A. Williams,
Yang An,
Nicole Armstrong,
Melissa KitnerTriolo,
Luigi Ferrucci,
Susan M. Resnick
Publication year - 2020
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-191268
Subject(s) - cognitive decline , cognition , neuropsychology , medicine , gerontology , disease , psychology , cognitive test , dementia , pathology , psychiatry
Alzheimer's disease (AD) is now understood to have a long preclinical phase in which pathology starts to accumulate in the absence of clinical symptoms. Identifying the temporal stages of accelerated cognitive decline in this phase may help in developing more sensitive neuropsychological tools for early screening of preclinical cognitive decline. Change-point analyses are increasingly used to characterize the temporal stages of accelerated cognitive decline in the preclinical stages of AD. However, statistical comparisons of change-points between specific cognitive measures have not been reported.