Open AccessOxidized Products of Omega-6 and Omega-3 Long Chain Fatty Acids Are Associated with Increased White Matter Hyperintensity and Poorer Executive Function Performance in a Cohort of Cognitively Normal Hypertensive Older Adults
Author(s) -
Lynne Shinto,
David Lahna,
Charles Murchison,
Hiroko H. Dodge,
Kirsten Hagen,
Jason David,
Jeffrey Kaye,
Joseph F. Quinn,
Rachel Wall,
Lisa C. Silbert
Publication year - 2020
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-191197
Subject(s) - epoxide hydrolase 2 , hyperintensity , dementia , arachidonic acid , polyunsaturated fatty acid , medicine , white matter , vascular dementia , chemistry , biochemistry , endocrinology , fatty acid , disease , magnetic resonance imaging , radiology , enzyme
Cerebrovascular disease is a common cause of dementia in older adults, and potentially preventable with early intervention. Oxylipins are produced from the oxidation of long-chain polyunsaturated fatty acids (PUFA) possessing potent vascular effects. Oxylipins generated from the cytochrome P450 pathway are enzymatically converted to diols by soluble epoxide hydrolase (sEH); sEH products have been associated with small vessel ischemic disease. Little is known about oxylipins' impact on markers of dementia risk.