Open AccessThe MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction
Author(s) -
Keith W. VanDusen,
Sarada S Eleswarpu,
Eugene W. Moretti,
Michael J. Devinney,
Donna Crabtree,
Daniel T. Laskowitz,
Marty G. Woldorff,
Kenneth Roberts,
John Whittle,
Jeffrey N. Browndyke,
Mary Cooter,
Frank Rockhold,
Oke Anakwenze,
Michael P. Bolognesi,
Mark E. Easley,
Michael N. Ferrandino,
William A. Jiranek,
Miles Berger,
Marble Study Investigators
Publication year - 2020
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-191185
Subject(s) - medicine , neuroinflammation , perioperative , delirium , adverse effect , placebo , cognitive decline , randomized controlled trial , anesthesia , neurocognitive , cognition , intensive care medicine , disease , psychiatry , dementia , pathology , alternative medicine
Perioperative neurocognitive disorders (PND) are common complications in older adults associated with increased 1-year mortality and long-term cognitive decline. One risk factor for worsened long-term postoperative cognitive trajectory is the Alzheimer's disease (AD) genetic risk factor APOE4. APOE4 is thought to elevate AD risk partly by increasing neuroinflammation, which is also a theorized mechanism for PND. Yet, it is unclear whether modulating apoE4 protein signaling in older surgical patients would reduce PND risk or severity.