Open AccessInflammation in Traumatic Brain Injury
Author(s) -
Teodor T. Postolache,
Abhishek Wadhawan,
Adem Can,
Christopher A. Lowry,
Margaret Woodbury,
Hina Makkar,
Andrew J. Hoisington,
Alison Scott,
Eileen Potocki,
Michael E. Benros,
John W. Stiller
Publication year - 2020
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-191150
Subject(s) - traumatic brain injury , context (archaeology) , psychological intervention , medicine , immune system , inflammation , neuroscience , clinical trial , physical medicine and rehabilitation , intensive care medicine , bioinformatics , psychology , immunology , pathology , psychiatry , biology , paleontology
There is an increasing evidence that inflammation contributes to clinical and functional outcomes in traumatic brain injury (TBI). Many successful target-engaging, lesion-reducing, symptom-alleviating, and function-improving interventions in animal models of TBI have failed to show efficacy in clinical trials. Timing and immunological context are paramount for the direction, quality, and intensity of immune responses to TBI and the resulting neuroanatomical, clinical, and functional course. We present components of the immune system implicated in TBI, potential immune targets, and target-engaging interventions. The main objective of our article is to point toward modifiable molecular and cellular mechanisms that may modify the outcomes in TBI, and contribute to increasing the translational value of interventions that have been identified in animal models of TBI.