Open AccessAssociations Between Depression, Traumatic Brain Injury, and Cognitively-Defined Late-Onset Alzheimer’s Disease Subgroups
Author(s) -
Julianna Bauman,
Laura E. Gibbons,
Mackenzie Moore,
Shubhabrata Mukherjee,
Susan M. McCurry,
Wayne C. McCormick,
James D. Bowen,
Emily H. Trittschuh,
M. Maria Glymour,
Jesse Mez,
Andrew J. Saykin,
Kristen Dams-O’Conner,
David A. Bennett,
Eric B. Larson,
Paul K. Crane
Publication year - 2019
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-181212
Subject(s) - depression (economics) , traumatic brain injury , psychology , clinical psychology , cognition , psychiatry , audiology , medicine , economics , macroeconomics
There is considerable heterogeneity in clinical presentation among people with late-onset Alzheimer's disease (LOAD). We have categorized people with LOAD into subgroups based on relative impairments across cognitive domains. These 6 groups are people with no relatively impaired domains (AD-No Domains), 4 groups with one relatively impaired domain (AD-Memory, AD-Executive, AD-Language, and AD-Visuospatial), and a group with multiple relatively impaired domains (AD-Multiple Domains). Our previous analysis demonstrated that genetic factors vary across cognitively-defined LOAD groups.