Open AccessA Potential Role for α-Amylase in Amyloid-β-Induced Astrocytic Glycogenolysis and Activation
Author(s) -
Elin Byman,
Nina Schultz,
Anna M. Blom,
Malin Wennström
Publication year - 2019
Publication title -
journal of alzheimer's disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.677
H-Index - 139
eISSN - 1875-8908
pISSN - 1387-2877
DOI - 10.3233/jad-180997
Subject(s) - amylase , glycogen , glycogenolysis , glial fibrillary acidic protein , endocrinology , glycogen synthase , lactate dehydrogenase , astrocyte , medicine , chemistry , biology , biochemistry , enzyme , immunohistochemistry , central nervous system
Astrocytes produce and store the energy reserve glycogen. However, abnormal large glycogen units accumulate if the production or degradation of glycogen is disturbed, a finding often seen in patients with Alzheimer's disease (AD). We have shown increased activity of glycogen degrading α-amylase in AD patients and α-amylase positive glial cells adjacent to AD characteristic amyloid-β (Aβ) plaques.