A Potential Role for α-Amylase in Amyloid-β-Induced Astrocytic Glycogenolysis and Activation | Zendy

Elin Byman | Zendy; Nina Schultz | Zendy; Anna M. Blom | Zendy; Malin Wennström | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

A Potential Role for α-Amylase in Amyloid-β-Induced Astrocytic Glycogenolysis and Activation

Author(s) -

Elin Byman,

Nina Schultz,

Anna M. Blom,

Malin Wennström

Publication year - 2019

Publication title -

journal of alzheimer s disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.677

H-Index - 139

eISSN - 1875-8908

pISSN - 1387-2877

DOI - 10.3233/jad-180997

Subject(s) - glycogenolysis , amyloid β , amyloid (mycology) , chemistry , neuroscience , psychology , biochemistry , medicine , glycogen , disease , inorganic chemistry

Astrocytes produce and store the energy reserve glycogen. However, abnormal large glycogen units accumulate if the production or degradation of glycogen is disturbed, a finding often seen in patients with Alzheimer's disease (AD). We have shown increased activity of glycogen degrading α-amylase in AD patients and α-amylase positive glial cells adjacent to AD characteristic amyloid-β (Aβ) plaques.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research